This is the final composition of this shot. Miles and Myrna heading in to town for some supplies. The background is an HDR, hand painted photograph I took in the woods near Lake Placid, New York.

Here is a working close up of Myrna, trying to get all of the facial hair going in the right direction before I hit the hard spots.
With the high resolution scan of the drawing done, now I can work out the color palette of these characters.
As I have said before, everything starts off as a drawing. I have gone straight to digital before, but I prefer to sketch everything out on paper first. The reworking is a better workflow for my style.